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15.26 years of chemical industry knowledge and experience.
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Common name: (R)-3-Piperidinamine dihydrochloride

Category:Trelagliptin & Alogliptin intermediates

Other name: R-3-AMnio piperidine dihydrochloride

CAS No.: 334618-23-4

EINECS No.: 608-870-9

Appearance: Powder

Molecular formula: C5H13ClN2

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

Product Specification:

Product Description:
(R)-3 - Piperidinamine dihydrochloride usually appears as a white to off - white crystalline powder. Structurally, it contains a piperidine ring, which is a six - membered heterocyclic ring with one nitrogen atom. At the 3 - position of the piperidine ring, an amino group (-NH?) is attached. The compound exists in its dihydrochloride salt form, meaning that the two hydrogen atoms from hydrochloric acid have formed ionic bonds with the nitrogen atoms of the amino group and the piperidine ring's nitrogen atom. This salt formation significantly affects its physical and chemical properties.

In terms of solubility, due to its salt nature, it has high solubility in water. The ionic bonds with the chloride ions enhance its hydrophilicity, allowing it to dissolve readily in polar solvents. In organic solvents, its solubility is relatively lower compared to water. Under normal storage conditions, it is relatively stable. However, exposure to strong bases can cause the liberation of the free amine form through a neutralization reaction, as the base reacts with the hydrochloric acid moieties.

In the fields of organic synthesis and pharmaceutical research, (R)-3 - Piperidinamine dihydrochloride is of great importance. In organic synthesis, it serves as a valuable building block for constructing more complex nitrogen - containing organic molecules. The amino group can participate in various reactions such as acylation, alkylation, and condensation reactions with different reagents. In pharmaceutical research, it may act as a potential intermediate for the synthesis of drugs with specific biological activities. Many drugs containing piperidine and amino - containing moieties have shown significant therapeutic effects in treating various diseases, and (R)-3 - Piperidinamine dihydrochloride can be used as a starting point to access such compounds. To maintain its quality and integrity, it should be stored in a cool, dry place, away from light, moisture, and strong bases.

Application: 

(R)-3-aminopiperidine dihydrochloride has been used as a reactant for the preparation of a dipeptidyl peptidase IV inhibitor derived from alogliptin.

Package: 25kg/drum or bag

Storage: Inert atmosphere, Room Temperature

Executive Standards: International Standard.