Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards.

Colorcom prides itself on superior customer and technical focus, while focusing on support, developing and manufacturing superior colorants and specialty chemicals. All of our industrial chemical manufacturing is executed to enhance the performance, appeal and processing of a broad range of products used in various industries and consumer - based applications.

The competitive advantages of Colorcom international as your business partner or supplier:

1.Established manufacturer.
2.Current ISO certified; REACH registered.
3.Track record of quality, Lot to lot consistency.
4.Zero defect, Return policy.
5.Sufficient inventory.
6.Wide product portfolio, A great choice of shades.
7.Joint product development.
8.Total innovative solutions for every industry of the specific requirements.
9.Open dialogue and communication channels.
10.Long term commitment to meet or exceed the expectations of customers.
11.Competitive pricing, Optimistic margin.
12.Providing efficient service which is second to none.
13.Constantly changing industry requirements for innovative, fully customized products and solutions.
14.Consistent color performance, adaptability, flexibility and customization.
15.26 years of chemical industry knowledge and experience.
16.Colorcom makes every effort to better serve the global customers,We create and bring the best values to you.

Common name: Dapagliflozin Tetraacetate

Category:Dapagliflozin intermediate

Other name: (2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

CAS No.: 461432-25-7

EINECS No.: 930-010-9

Appearance: Powder

Molecular formula: C29H33ClO10

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

Product Specification:

Product Description:
Dapagliflozin Tetraacetate commonly presents as a white to off - white powder. Structurally, it is derived from dapagliflozin, where four hydroxyl groups of dapagliflozin are acetylated to form acetate esters. These acetate groups not only change the physical properties of the original dapagliflozin but also have an impact on its chemical reactivity. The acetyl moieties add a certain degree of lipophilicity to the molecule, which can influence its solubility and membrane - permeability characteristics.

In terms of solubility, compared to dapagliflozin, Dapagliflozin Tetraacetate shows different solubility profiles. It has lower solubility in water due to the increased lipophilicity from the acetate groups, but enhanced solubility in some organic solvents like ethanol and chloroform. In chemical reactions, the acetate esters can be hydrolyzed under acidic or basic conditions to regenerate the original hydroxyl - containing dapagliflozin. This hydrolysis reaction can be carefully controlled to release dapagliflozin in a targeted manner.

In the field of pharmaceutical research and drug development, Dapagliflozin Tetraacetate holds potential importance. It may be used as a prodrug form of dapagliflozin. The acetate - protected form can improve the drug's stability during storage and transportation, and upon administration, the acetate groups can be cleaved in the body to release the active dapagliflozin. This can potentially enhance the bioavailability and therapeutic efficacy of dapagliflozin. Additionally, in some synthetic routes for preparing dapagliflozin - related derivatives, Dapagliflozin Tetraacetate can serve as an intermediate. To maintain its quality and integrity, Dapagliflozin Tetraacetate should be stored in a cool, dry place, protected from light, heat, and moisture. High humidity and extreme temperatures can accelerate the hydrolysis of the acetate esters, leading to the degradation of the compound.

Application: 

It can be used as chemical intermediates for organic synthesis and experimental research, commonly used as organic chemical raw materials, can be used to make spices, and is also an intermediate for the synthesis of a variety of drugs in the pharmaceutical industry.

Package: 25kg/drum or bag

Storage: Sealed in dry, Room Temperature

Executive Standards: International Standard.