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1.Established manufacturer.
2.Current ISO certified; REACH registered.
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4.Zero defect, Return policy.
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7.Joint product development.
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14.Consistent color performance, adaptability, flexibility and customization.
15.26 years of chemical industry knowledge and experience.
16.Colorcom makes every effort to better serve the global customers,We create and bring the best values to you.

Common name: 8-Bromo-3-methyl-xanthine

Category:Linagliptin intermediates

Other name: 8-Bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione

CAS No.: 93703-24-3

EINECS No.: 819-117-0

Appearance: Powder

Molecular formula: C6H5BrN4O2

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

Product Specification:

Product Description:
8 - Bromo - 3 - methyl - xanthine usually presents as a white to off - white crystalline solid. Structurally, it belongs to the xanthine family, sharing a purine - derived ring system with 3 - methylxanthine. However, it has an additional bromine atom at the 8 - position, in addition to the methyl group at the 3 - position. This bromine substitution significantly impacts the molecule's properties. The bromine atom, being large and electronegative, can influence intermolecular interactions, such as increasing the compound's polarity to some extent. The fused - ring structure, consisting of a pyrimidine ring and an imidazole ring, maintains a planar and rigid conformation, which is essential for its biological and chemical activities.

In terms of solubility, compared to 3 - methylxanthine, the presence of the bromine atom can slightly alter its solubility profile. It still has low solubility in water, but its solubility in polar organic solvents like ethanol and dimethyl sulfoxide (DMSO) may be affected due to the change in molecular polarity. Under normal storage conditions, it is relatively stable, yet exposure to high temperatures, strong acids, or bases can lead to decomposition or chemical reactions. For instance, in strong basic conditions, the bromine atom might be involved in substitution or elimination reactions.

Pharmacologically, 8 - Bromo - 3 - methyl - xanthine shows similar inhibitory effects on phosphodiesterase enzymes as 3 - methylxanthine, which results in an increase in intracellular cyclic AMP levels. This can lead to effects such as smooth muscle relaxation and central nervous system stimulation. However, the bromine substitution may also confer some unique biological activities. Clinically, it is being investigated for potential applications in treating certain disorders related to abnormal cell signaling, taking advantage of its ability to modulate cyclic AMP levels. In chemical research, it serves as a valuable intermediate for the synthesis of more complex xanthine - based derivatives. To maintain its quality and stability, it should be stored in a cool, dry place, away from direct sunlight, moisture, and reactive chemicals.

Application: 

Liralitine intermediates.

Package: 25kg/drum or bag

Storage: Under inert gas (nitrogen or Argon) at 2–8 °C

Executive Standards: International Standard.