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Common name: 2-cyano-5-fluorobenzylbroMide

Category:Trelagliptin & Alogliptin intermediates

Other name: 2- cyano -5- fluorine benzyl bromide

CAS No.: 421552-12-7

EINECS No.: 675-637-6

Appearance: Solid

Molecular formula: C8H5BrFN

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

Product Specification:

Product Description:
2 - Cyano - 5 - fluorobenzylbromide typically presents as a colorless to light - yellow liquid or a crystalline solid, depending on the storage conditions. Structurally, it consists of a benzene ring with a cyano group (-CN) at the 2 - position, a fluorine atom at the 5 - position, and a bromomethyl group (-CH?Br) attached to the benzene ring. The cyano group is highly reactive due to the presence of the triple - bonded carbon - nitrogen moiety. It can participate in various reactions such as nucleophilic addition and condensation reactions. The fluorine atom, being electronegative, affects the electron density of the benzene ring, influencing the reactivity of the adjacent carbon atoms. The bromomethyl group is extremely reactive, especially towards nucleophiles. The bromine atom's high electronegativity makes the carbon atom in the -CH?Br group a good target for nucleophilic substitution reactions.

In terms of solubility, it has low solubility in water because of the non - polar nature of the benzene ring and the hydrophobic groups attached to it. However, it is soluble in common organic solvents like dichloromethane, chloroform, and ethyl acetate. Under normal storage conditions, it should be handled with care as it is sensitive to moisture and heat. Moisture can lead to hydrolysis of the bromomethyl group, while heat can accelerate decomposition or unwanted chemical reactions.

In the field of organic synthesis, 2 - Cyano - 5 - fluorobenzylbromide is a crucial building block. It can be used to synthesize a wide variety of compounds by reacting with different nucleophiles. For example, reacting it with amines can lead to the formation of new carbon - nitrogen bonds, enabling the synthesis of complex nitrogen - containing organic molecules. In pharmaceutical research, it may serve as a potential intermediate for the synthesis of drugs with specific biological activities. Modifying the substituents on the benzene ring or reacting the functional groups with different reagents can potentially lead to the discovery of novel bioactive substances. To maintain its quality and reactivity, it should be stored in a cool, dry environment, away from light, moisture, and strong oxidizing or reducing agents.

Application: 

2-cyano-5-fluorobenzyl is used as an intermediate in pharmaceuticals such as troliptin.

Package: 25kg/drum or bag

Storage: 2-8°C

Executive Standards: International Standard.