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Common name: 4-(4-Piperidyl)-1-butanol

Category:PROTAC linker

Other name: 4-(piperidin-4-yl)butan-1-ol

CAS No.: 57614-92-3

EINECS No.: /

Appearance: Powder

Molecular formula: C9H19NO

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

Product Specification:

Product Description:
4-(4 - Piperidyl)-1 - butanol usually exists as a colorless to light - yellow liquid or a semi - solid at room temperature, depending on its purity and storage conditions. Structurally, it features a four - carbon butanol chain with a piperidine ring attached at the 4 - position. The piperidine ring, a six - membered heterocyclic structure containing a nitrogen atom, imparts basic properties to the compound. The hydroxyl group at the end of the butanol chain provides the molecule with hydrophilicity and reactivity, allowing it to participate in reactions such as esterification with carboxylic acids and etherification with alkyl halides.

In terms of solubility, it has some solubility in water due to the presence of the polar hydroxyl group, but it is also soluble in a wide range of organic solvents like ethanol, methanol, and chloroform. The basic nitrogen atom in the piperidine ring can react with acids to form salts, which can significantly change its solubility and physical properties. In chemical reactions, the piperidine nitrogen can act as a nucleophile in various substitution and addition reactions. For example, it can react with electrophiles such as alkyl halides in an SN2 - type reaction to introduce new substituents on the nitrogen atom. The hydroxyl group can be oxidized to form carbonyl - containing compounds under appropriate oxidizing conditions.

In the fields of organic synthesis and pharmaceutical research, 4-(4 - Piperidyl)-1 - butanol is of great importance. In organic synthesis, it serves as a versatile building block for constructing more complex molecules. The combination of the piperidine ring and the butanol chain allows for the creation of diverse chemical structures through reactions involving the nitrogen atom of the piperidine and the hydroxyl group of the butanol. For instance, it can be used in the synthesis of compounds with potential biological activities by forming amide or ether linkages. In pharmaceutical research, it can be a starting material for the development of drugs that target specific biological processes. Modifying the substituents on the piperidine ring or the butanol chain can potentially lead to the discovery of novel bioactive substances. To maintain its quality and reactivity, it should be stored in a cool, dry place, away from strong oxidizing agents, heat, and light.

Application: 

In organic synthesis, 4-(4 - Piperidyl)-1 - butanol is a versatile building block for constructing complex molecules, forming diverse structures through reactions of the piperidine nitrogen and butanol hydroxyl group. In pharmaceutical research, it serves as a starting material for drugs targeting specific biological processes, and modifying its structure may lead to novel bioactive substances.

Package: 25kg/drum or bag

Storage: Keep in dark place, Inert atmosphere, Room temperature

Executive Standards: International Standard.